Observational Study Designs: Synopsis for Selecting an Appropriate Study Design

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Abstract

The selection of a study design is the most critical step in the research methodology. Crucial factors should be considered during the selection of the study design, which is the formulated research question, as well as the method of participant selection. Different study designs can be applied to the same research question(s). Research designs are classified as qualitative, quantitative, and mixed design. Observational design occupies the middle and lower parts of the hierarchy of evidence-based pyramid. The observational design is subdivided into descriptive, including cross-sectional, case report or case series, and correlational, and analytic which includes cross-section, case-control, and cohort studies. Each research design has its uses and points of strength and limitations. The aim of this article to provide a simplified approach for the selection of descriptive study design.

Keywords: observational, study design, descriptive, retrospective, prospective, strength

Introduction and background

A research design is defined as the “set up to decide on, among other issues, how to collect further data, analyze and interpret them, and finally, to provide an answer to the question” [1]. The primary objective of a research design is to guarantee that the collected evidence allows the answering of the initial question(s) as clearly as possible [2]. Various study designs have been described in the literature [1-3]. Each of them deals with the specific type of research or research questions and has points of strength and weakness. Broadly, research designs are classified into qualitative and quantitative research and mixed methods [3]. The quantitative study design is subdivided into descriptive versus analytical study designs or as observational versus interventional (Figure ​ (Figure1). 1 ). Descriptive designs occupy the middle and lower parts of the hierarchy of evidence-based medicine pyramid. Study designs are organized in a hierarchy beginning from the basic "case report" to the highly valued "randomised clinical trial" [4-5].